New2MeOS
The ability to create multiple profiles is fantastic.
This isn't a GrapheneOS specific feature, but we do have relevant improvements to it and normally Google Play can't be contained to a profile and has cross-profile access since outside GrapheneOS it can't be used as regular sandboxed apps rather than being deeply integrated OS components with extensive access.
Orbot tends to disconnect randomly.
Orbot is poorly written, buggy and inefficient. Tor is making their own Tor VPN app to replace it. Orbot doesn't have great compatibility with modern Android and lots of issues. This is not caused by GrapheneOS.
Nest app does not load.
You might be missing dependencies for it. Try installing the Google Search app too. Try searching the forum for this.
ProCam X Lite is a nice alternative to the native camera app. Even so, I think the pictures on the S22 Ultra are a bit better
You can use Pixel Camera for the same experience as the stock Pixel OS. Our own Camera app is going to be improved to catch up in various ways but Pixel Camera is hard to compete with and can be used on GrapheneOS.
Meta products - mixed bag
These apps work fine on GrapheneOS. They partially depend on Google Play but can work without it. To have WhatsApp, etc. work properly without it, you need to change some things.