- Edited
I'm undecided about the current situation with Vanadium lacking blocking. That said, I have been using it for a few weeks to see how I feel about it.
Third party scripts served by sites are clearly a threat to privacy and have been used as an attack vector. Ad and third-party script blocking in a browser (I user uBlock on my desktop) serves as a first-line defence against these.
I use Pi-hole (and via a personal VPN when on cell data) to defend my phone and desktops. But it cannot be as capable a blocker as one in-browser. Most users probably don't use Pi-hole 100% of the time if at all, so do not have any protection; there is no defence in-depth.