TalentedQuill I'm disappointed that despite my efforts in the original post this still became yet another thread with browser suggestions
You got an answer to your original post, the answer is no, so, the only alternative for what you want is to use a front-end or another browser that blocks ads better.
TalentedQuill Would it be possible to compile Vanadium myself to add uBlock Origin support or something along those lines?
UBlock Origin is no longer available on Chromium, gorhill has removed it. Only uBlock Origin Lite, which is the MV3 version, is available on the Chrome Web Store.
What's more, Vanadium doesn't support extensions at all, so I don't know if compiling it yourself with modifications can allow you to use the extensions, you won't get Vanadium at the end.
Laurent DNS-based ad blocking is ineffective on Youtube.