I tried to keep a system setup as simple as possible based on my threat model.
I have only the Owner profile with the Google Play apps installed. Most of the app I use are FOSS. Everything comes from the Play Store.
Basically, if I can use Vanadium to access a service I do, unless there is a FOSS app that exists to perform the same task.
I would have loved to avoid Google entirely, but I still need some apps from the Play Store and the FIDO2 capabilities of my Nitrokey in Vanadium.