elih it's a question of which VPN provides the best privacy and anonymity among all VPN providers.
GOS+Vanadium+Orbot as Full VPN. Disable JIT and javascript globally. You will still be able to enable javascript for a specific web page directly from Vanadium. Vanadium supports .onion links directly, so there is no reason to install Tor Browser. There is a small issue in Vanadium that .onion addresses are marked as insecure. I plan to report this to the Vanadium developers as a bug.
Network & Internet -> VPN -> Always-on VPN + Block connections without VPN. This will prevent leaks such as DNS.
This is the best setup you can easily do. A more advanced approach is to hide Tor behind a socks5 proxy, which will avoid Tor being blocked by endpoint servers, but I was surprised that my banking app works even when I connect directly through Tor.
Separate profile: Wireguard/WG Tunnel or e.g. Mullvad/IVPN/Proton. This solution is good when you are more concerned about bypassing geoblocking. VPN will also work well in hotels, cafes, etc., when you want to hide your outgoing traffic.