Some people argue that F-Droid isn't as safe as Play Store. However, there are arguments against Play Store as well (you have to trust Google, for one...). I don't remember all the details, but I've done some digging into it. My conclusion is that I'm comfortable and happy with F-Droid clients (F-Droid, F-Droid Simple, Droid-ify, Neo Store etc.)
Personally I currently use Droid-ify but I think I'll move over to Neo Store (it has some additional nice features and development seems to be more active (looking at the git)). Both apps have the ability to save a list of favorite apps and have export/import functionality. Neo Store can export installed apps and import a list of apps and install all of them.
Creating a setup for later migration is very neat.
The reason for using alternatives to F-Droid is additional functionality. One of which is a toggle to enable other repositories (like IzzyOnAndroid, created by one of the F-Droid developers). With F-Droid, you have to manually add them. Also, having import/export functionality in Droid-ify and Neo Store makes it much easier to just import your favorite setup. Neo Store also have indicators of trackers and permissions for apps and you can filter/sort by licence, permitted anti-features, repositories and generally has more features. It's quite customizable, so you can disable some of the things you don't want.
F-Droid and F-Droid Simple might be easier to use, but more difficult to set up well (because the need to manually find repos and manually add apps e.g. after moving to a new phone). But I wouldn't say Droid-ify and Neo Store are very hard to use (sometimes easier, like mentioned). Like with everything, you have to learn a few things when trying something new for the first time, that's true for everything in life.
I had some issues with apps not automatically updating previously (it was an issue with Android or GrapheneOS and the developers have been aware of it). I moved over to F-Droid Simple and at some point automatic updating worked and I then moved over to Droid-ify and it worked there also. I haven't tried F-Droid again but I assume the issue was fixed in an OS patch at some point.
I haven't verified if this works in Neo Store. Note: You always have to install manually once, then afterwards it is able to automatically update. You don't have to reinstall, just update manually once in the new store app.