I work with several profiles, whereby my owner profile is only used to install and distribute apps to the other profiles. I use different profiles either for security reasons (banking apps in a separate profile) or for privacy reasons (one profile with apps that require Google Play services and a main profile that does not require Google services) - to avoid IPC..
I switched from a normal Android phone to GrapheneOS and didn't work with profiles before. At the beginning it was a bit tricky when you had to go into the owner profile for certain settings (e.g. opening a hotspot, activating the eSIM) - but after a while you get the hang of it. If the app communication feature of GrapheneOS is introduced, I could imagine - if IPC can be prevented with it - merging the Google and degoogled profile - for convenience. Otherwise, I would keep it - I've gotten used to it by now.
What problems have you encountered with SMS?