n3t_admin It makes no difference whether you run Shizuku on stock Android, Lineage or Graphene.
I feel as if this is somewhat ill-defined. GrapheneOS has a bunch of hardening, for example MTE on newer devices and hardened_malloc regardless, that, strictly speaking, isn't necessarily negated by Shizuku.
But it might be negated in practice. Maybe Shizuku and/or LSPatch or the whatever module trips MTE or trips hardened_malloc, in which case they'd be turned off and thus not adding any security. Plus I don't think the OP said which device, so maybe there isn't MTE anyway.
I don't think it's the responsibility of this forum to be "helpful" in untangling all of these nuances and contingencies.
Meanwhile arguably there is some responsibility to warn passers-by that there are real risks that have not been investigated.