GolemSnow Is there a way to backup the whole profiles instead of per app (that I am currently doing)?
GrapheneOS has a built-in backup feature called Seedvault which is able to do this partially. Settings > System > Backups. I say partially because not all system settings that you have changed will be backed up. Settings like the home screen layout and quick tiles will be backed up. It is able to backup the apps within a profile (also the disabled apps), but it cannot backup and restore the app data for all of those apps. For example, Signal/Molly have their own backup system and won't be compatible with system backup software; Seedvault will tell you that their app data were backed up but you won't be able to use their restored app data. For that reason, I strongly recommend to take manual backups of the app data as well where you can.
Note that Seedvault backups are per-profile. You will have to create backups for each of your profiles.
Seedvault is not known as a hugely reliable backup system, but in my experience it mostly works. It has become slightly easier to use in the latest versions. It's convenient when it works.
It doesn't support backing up private spaces to a USB stick. Note that apps will have their Network permission enabled when they are restored.