To the best of my understanding, you can make just about anything that works on android to also work with GOS.
The question is more about how much on the way of permissions and compromises do you need to accept to get them to work?
Even if you have to install google play services and allow connections to a bunch of trackers and whatnot, you'll still benefit from security improvements and a higher level of control over what your phone does over base AOSP and Stock Pixel OS.