- You can put your data at rest quickly and easily without rebooting
- Don't need to erase your phone to erase data. Just delete profiles with sensitive data.
- after a reboot, personal data is behind two passwords/PINs
- a very easy way to do battery saving if a personal profile has VPN or Google Play Services running all the time, taking up battery
- sensitive global system settings are in the owner profile. If the owner profile only accepts a password/PIN, no biometrics, the phone would be a little safer
There might be more advantages I didn't think of.
I do this, personally. I find only one drawback to this method, which is it's a bit of a nuisance to switch back and forth sometimes when I need to make changes to system settings. However, I find it worth the extra effort.