mascarin here's my setup
Pixel 6a
Owner Profile - I use this profile for all my main private apps without trackers. (Including calls and texts). These are only apps I can trust 100%.
Profile 2 - This is my 'untrusted apps' profile. Basically any apps that I want/need go here. They usually have trackers and thats why they go here.
Banking Profile - This profile only has my bank app. I like to keep it separate.
Private Space (in Owner Profile) - I use private space for untrusted apps that require verification codes. Its easier to unlock it and get my code via SMS rather than switch profiles and usually lose my progress in the app.
Other people will set up another profile with Google Play if they need that (I don't use Google Play).
Thats my setup. Hope it helps. :)