Plethora9278
If you enable the compatibility mode, all of the exploit protections gets turned off for that app, including Secure app spawning.
Most apps work with the protections enabled, and there's very few apps that need you to turn all protections off. So, if you got the time to disable them one at a time and try again, that is better since e.g. Hardened Memory Allocator is almost never a problem for an app to run.