I tried to use GOS with disabled animations, turned off in the normal accessibility color and motion setting. Didn't go into dev options for that.
What happens now is that the private space in my main profile, won't load the application icons which I have installed there. They can still be clicked but they are invisible. After reenabling animations, they appeared again. I tested this after restarts.
Furthermore the app drawer often becomes useless, when being opened from homescreen instead of within an app, it is not loading the apps to be selected properly, and the windows can't be clicked.
The fingerprint detection seems to also skip through several detections within a second, as there are no "fingerprint fail detect animation", resulting in having to enter the password/pin manually sometimes.
Overall, I like the setting, because you can be faster with disabled animations. But I had to turn it off for now, because of these issues.