zehyani
Hi @zehyani,
you can use two SIMs with one profile, if you mean Dual SIM with one eSIM and one SIM card or two eSIMs w/o SIM card (no plastic).
In other words: yes, it's possible.
And for the sake of completeness: if you live in a country where the Pixel is available with two SIM slots, the same applies as mentioned above (dual SIM), only with two SIM cards instead of one eSIM and one SIM card.
BTW: You can't use one SIM for profile A and another SIM for profile B. But that wasn't your question, I know. ;-)