Brave as main (begrudgingly, don't like some stuff about it but it's best in class for anti fingerprint which is set to "strong") and Vanadium as a backup since my Brave setup breaks some sites. I used to love Bromite until it became obvious that it's not well maintained update-wise.
I also have ad blocking via VPN (both Mullvad and IVPN depending on the device) and thanks to them there are no ads on Vanadium for me. You might want to try NextDNS if you don't use a VPN service, I've heard many good things about them. Also NewPipe Sponsorblock for YouTube. The only ads I get are audio ads in Podcasts (Antennapod).
Edit: Added info