I'm using GrapheneOS since one week on a Pixel 6a. My setup is, that I use the main profile for FOSS-Apps only and distribute all non-FOSS apps over several task related profiles (Banking, Access, Messaging, Gaming etc.). Furthermore I have a profile called Pixel, which is "googelized" and where all apps that heavily depend on Google live.
I think during setup of the phone, I installed the Google Services Framework in the main folder (I think because of the eSIM). Some days ago I deleted it from the main profile but kept it installed on the Pixel profile.
Interestingly, when the Google Services Framework is removed from the main profile, all Google Apps such as Maps, Playstore, or Camera crash on the Pixel profile. Even reinstalling the Apps does not help. They start to working again after I installed the Google Services Framework in the main profile again.
I can live with the Google Services Framework in the main profile, as this seems to be a passive library only, but I am curios if there is a technical reason or if this is just a bug.