Graphene1
In my experience, yes. I transitioned all of my apps (well all the apps that have its APK on github or own website that is) to Optanium a month ago and I had to reinstall said apps as Obtanium couldn't update them.
Luckily for me all the apps in question had the option to export/import settings and data so it wasn't such a big deal for me.
After the initial hassle I've been a happy camper though. Obtainium is a real gem.