Koopa I have cleaned all cavities with isopro alcohol, toothbrushlike brush
With the few pixel phones I have used, they have a screen over the speaker and microphone hole at the bottom so I try not to push on it too much so it remains glued to the frame. Once it's dislodged, I'd imagine dirt could get in there.
Something to consider. Sounds like a hardware issue. You could try sideloading a full OTA .zip file. This will replace all of the OS and the process does not deliberately delete your data. Do not do anything in developer options for this. Turn off developer options -- this could be your issue.
https://grapheneos.org/usage#updates-sideloading
Settings > about phone > build number
Match that number to the end of one of the URLs below and use that file.
Normal
https://releases.grapheneos.org/tegu-ota_update-2026092500.zip
Security preview
https://releases.grapheneos.org/tegu-ota_update-2026092501.zip
Not really a fix but maybe a video call using the rear camera would use the other microphone on the back. You could record a short video using the rear camera and listen to see if that one has issues.