I have been using GOS for close to 2 years on my Pixel 8 (plain), and I am yet to encountered any hardware related problems.
I have not tried eSIM, wireless charging or Android Auto.
However, BT (audio), NFC, WiFi, GPS, Camera (apart from Google explicitly nerf-ing the camera unless using Google's camera app), USB (tethering, file sharing) etc. worked without issues for me.
That said, I bought the phone straight from Google, so this is not some handicapped second hand Verizon floor model or whatever, so YMMV.