I thought Yubikey would not work to unlock Keepass. HMAC-Secret is supported but only if you set up all credentials at once and the secret must not be generated on the keys which is a security risk. In an ideal world you could set up several FIDO2 credentials as login methods. But afaik this is not possible to date and and it is not a GOS problem.
I would not use a crummy way of unlocking the databasd because a failure or loss i.e. of the Yubikey could lock you out of your database.