lark6995 i had a similar issue a while ago on one of the services i reverse proxy to, and the cause was CORS related. I didn't confige something right but it worked, then chrome based browsers updated and became stricter relating CORS and didn't work anymore till i looked into it and fixed the misconfigurarion.
On another note, perhaps through an update of firefox, ar u sure the option 'use third party CA certificates'(Allows third party certificates from Android CA store) is still enabled?
Perhaps its an option to check on desktop firefox if u have the same issue, if so perhaps developer tools might indicate the issue?
I don't think it is GrapheneOS related, since i have no issues on IronFox with a self signed caddy cert, which i mainly only use for this purpose. I Don't have Memories but i do have a nextcloud instance, i'll try that app if i just can enter my nextcloud domain and report back.