Im confussed by your term of "work profiles"...
I think they are "other user" profile in technical OS terms.
Work or personal or google or social_media profiles, are just other user profiles but adapted at logical & usage level by the owner.
In the other profile called work ot personal, i would configure applications and settings to match the usage of the "user profile",eventually combined with personal private space.
Remmeber that lets say Firefox installed in owner profile can be pushed assigned to another user profile from the owner users management setup. Is the same applications but locked & isolated settings per app,per profile,per space.
However,if you install Firefox in the other user profile,is standalone AND cannot be a lower version,running standalone in that profile.
Same,in a locked personal space,installing,adding Firefox creates another instance,a third app if i can say so,with its own settings.
Im using Rethink on all profiles and spaces.
In a profile,is installed in the profile and eunning there AND is installed and running in private space ! They dont see each other,have separated folders and...not the same access and reporting logs !