Thanks for the reply. So you're saying the likelihood of a sophisticated compromise is extremely low, thanks to modern hardening like MTE on the Pixel 8.
At the same time though, a factory reset is not a trivial action. It involves days of reinstalling and configuring secure apps, self-hosted clouds and calendars, re-establishing encrypted backups, etc.
I've used multiple smartphones with /e/OS and LineageOS over the years. Maintained one LOS device for a while. And I haven't seen this kind of persistent and considerable degradation in speed before, which is why I'm exploring whether there's more targeted diagnostic tools available that work with GrapheneOS. If the only viable path to troubleshooting is a factory reset "gamble" even though the problem may return because my usage pattern hasn't changed (without understanding why this is necessary or resetting only a single system app in stead), then the cost in terms of time and usability starts to outweigh the security benefit for me. In the same time spent reconfiguring the phone, I can earn and purchase a Murena or Fairphone with /e/OS, and with those I know the issue won't return with my set of apps.
In other words, I'm looking for a way to diagnose the performance bottlenecks in a more granular way. If the time comes to do a factory reset without knowing what happened, I will sell the phone.