JohnPrivacy
No it is not possible, users can only make 1 work profile in the Owner.
TLDR for below quote: The new VM feature that is being developed will allow better isolated "profiles" for users to utilise. Until then, users can either make use of Private Space and the Work profile (currently both 1 in Owner profile only) or make multiple user profiles.
Long quote (sorry) taken from this post: https://grapheneos.social/@GrapheneOS/114146753338459416
Private Space is a new feature added in Android 15 that's fully supported by GrapheneOS. It's similar to a work profile but avoids the need for a management app since the UI for managing it is built into the OS. It also avoids a lot of weirdness tied to having a management app. It has better integration for sharing files between them, etc. in the native OS UI. It also fully supports having a separate lock method.
Once there's support for creating more than one Private Space, there will be almost 0 reason left to know or care about work profiles beyond the actual intended use case of an actual work-managed profile via a remote device management system.
The remaining use case of a work profile for now is that you can't have more than 1 Private Space so you can continue using a work profile as a 2nd poor man's Private Space.
Private Space is closer to being a secondary user due to better UI integration, no need for a management app and full support for a separate lock method / encryption keys similar to a secondary user instead of the weird way it works with work profiles. We look forward to simply being able to tell people not to use work profiles for personal use but we can't yet because it's useful having 2 nested profiles rather than 1.
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Work profiles are not meant for personal use and most people are not meant to know about them. The Android community used them as a poor's man Private Space before they made that feature. Private Space and OEM features similar to it were likely at least partially inspired by how people were using work profiles via local management app.
Private Space is essentially just meant to be a nested user owned by another user.
In the future, support for having multiple Private Spaces would largely replace 1 person using multiple secondary users.
Android intended secondary users to be for actual separate people using the same device and work profiles to only be for Bring Your Own Device enterprise deployments where your work phone is nested inside your current phone and managed/owned by your work's device management system rather than by you.
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GrapheneOS has user-facing VM support now by the way since it's a standard Android 15 QPR2 feature with hardware support on the Pixel 6 and later (all supported devices). Our next release is adding GUI, speaker and microphone support along with opt-in GPU acceleration support which is all standard code we've backported from the AOSP main branch. Pixels use pKVM + CrosVM for virtualization, similar to ChromeOS.
GUI support is currently for a whole virtual machine desktop but it will end up being integrated with support for using specific applications in a VM similar to ChromeOS. In our next release, you'll be able to make 1 VM per user instead of just in Owner and the Private Space. You can still temporarily only use 1 at a time because of some minor things that need to be added upstream. Both limits will go away later.