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I highly recommend this guide comparing messengers, really helped me understand all the variables to consider:
https://www.messenger-matrix.de/messenger-matrix-en.html
Based on the link above, and without any personal experience with it, the only real complaints I'd have with Threema are that:
its centralized
(potentially bigger censorship / LE targeting risk)
and costs money
(potentially harder to convince contacts to sign up and use it with you)
Nothing is perfect though, and its pretty impressive that those are the only real nags I can see for Threema.
For example, Signal is also centralized.
Likewise, Signal is free, but you could argue its a bad thing because it means the bulk of their money comes from wealthy philanthropists, and maybe that's undesirable compared to a more "honest business model" approach with paying users.
Signal even has more nags besides these two variables (USA jurisdiction, no web browser support, big tech infrastructure hosting, no cross-platform restore from backup files, desktop client is far less secure than mobile apps, etc).
I still like Signal though, despite all the nags. It definitely hits a sweet spot for many folks.
Seems like Threema has a lot to offer too.
Of course usability / convenience features are also a factor. But I've never used Threema so I can't comment on that.