I've been using Graphene OS for 10 months on my Pixel 6 Pro. I use grayscale color correction to reduce dopamine response when I use the phone. When turning off color correction, no change happens. The device stays in whichever color profile is set. I have to restart the device for the change to take effect.
In the morning I often have to manually turn Night Light (which is scheduled) on then back off to get it to turn off. Maybe the two are related.