Xtreix
I think they're asking how other people isolate their apps, what apps they put into what profile, etc. Naomi Brockwell gives her own example in her latest video. I'm actually interested to hear other people's opinions as well since I'm in the process of isolating my apps, but I haven't decided on a setup yet. It's not as simple as "one profile for GSF" because I'd end up using multiple profiles with GSF. It's not an easy answer really.
Are you suggesting App Communication Scope will make profiles redundant (or generally increase sandboxing further)? Personally I would still make use of it entirely for the reason that I can use a different credential for more sensitive data.