JN2020 I learned after the fact that I should create profiles to do different tasks on.
Segregating your use cases into each distinct profile is something you can do, but not something you have to do. That's the beauty of GrapheneOS; full FOSS, de-googled setups, personal stuff away from work related activites, mix match everything into one pot, the choice is yours. The privacy improvements are massive either way. Think about what you are looking to achieve and go from there. There is no right or wrong here.