yakabb
Apart from the status bar, which you use to swipe down from the height of the camera, I can't think of any gestures that would be affected by your setup. Please help me out as i can't figure out: When do you have to swipe up to the camera?
Just to make sure - you know the option to deactivate the camera and microphone via toggle, right?
Placing the tiles "mic access" and "camera access in the Quick Tiles, deactivating them permanently and only activating them when required is a setup that I've often come across here in the forum.
In an interview, a GrapheneOS developer answers the interviewer's question of what additional security is offered by hardware switches (covering your camera counts as a hardware switch, I would guess) that could be installed by third-party companies compared to deactivation of the camera and microphone via software toggles, which seems to be deeply rooted in the system (apps cannot simply override your settings).
https://www.youtube.com/watch?v=WkQ_OCzuLNg
You might find this info helpful, unfortunately I can't remember exactly when the topic is brought up - I would guess it's in the last third of the interview.