vontroxler Of course it depends on the situation in question, but if you want to protect your data as much as possible, you could turn your phone off. That will purge the encryption keys from memory, reducing your attack surface a lot. As far as I understand anyway, there are far more knowledgeable people here.
Edit: that is another benefit of user profiles, if you end session of a user profile, it puts the data of that profile back at rest while your phone remains on.